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Heroin addict Mark Renton stumbles through bad ideas and sobriety attempts with his unreliable friends --Sick Boy, Begbie, Spud and Tommy. He also has an underage girlfriend, Diane, along for the ride. After cleaning up and moving from Edinburgh to London, Mark finds he can't escape the life he left behind as Begbie and Sick Boy come knocking.

The story of how George Jung, together with the Medellín Cartel led by Pablo Escobar, established the billion-dollar cocaine empire in the United States in the 1970s.

A high school basketball player’s life turns upside down after free-falling into the harrowing world of drug addiction.

A chronicle of the crimes of Ted Bundy, from the perspective of his longtime girlfriend, Elizabeth Kloepfer, who refused to believe the truth about him for years.

After he and his first wife separate, journalist David Sheff struggles to help their teenage son, who goes from experimenting with drugs to becoming devastatingly addicted to methamphetamine.

A precocious and obsessive teenager develops a crush on a naive writer with harrowing consequences.

The drug-induced utopias of four Coney Island residents are shattered when their addictions run deep.

Rachel Watson, devastated by her recent divorce, spends her daily commute fantasizing about the seemingly perfect couple who live in a house that her train passes every day, until one morning she sees something shocking happen there and becomes entangled in the mystery that unfolds.

A substance-addicted actress tries to look on the bright side even as she's forced to move back in with her mother to avoid unemployment.

A quiet, stoic man, lives a monk-like existence in self-imposed exile. When his estranged son is killed in a drug deal gone bad, he is left to look after a granddaughter he never knew existed, and he is forced back into a life he tried to put behind him.

Kate lives a secluded life—until her troubled daughter shows up, frightened and covered in someone else's blood. As Kate unravels the shocking truth, she learns just how far a mother will go to try to save her child.

A college freshman returns to Los Angeles for Christmas at his ex-girlfriend's request, but discovers that his former best friend has an out-of-control drug habit.

When a seemingly straight-forward drug deal goes awry, XXXX has to break his die-hard rules and turn up the heat, not only to outwit the old regime and come out on top, but to save his own skin...

The story of Richard Wershe Jr., a teenager who became an undercover informant for the police during the 1980s, and was ultimately arrested for drug trafficking and sentenced to life in prison.

This documentary follows three women — a fire chief, a judge, and a street missionary — as they battle West Virginia's devastating opioid epidemic.

An urgent phone call pulls a Yale Law student back to his Ohio hometown, where he reflects on three generations of family history and his own future.

A poet falls in love with an art student, who gravitates to his bohemian lifestyle — and his love of heroin. Hooked as much on one another as they are on the drug, their relationship alternates between states of oblivion, self-destruction, and despair.

A young drug-addled writer approaching the bottom of his descent submits to two months of agonizing detox at a treatment center in Minnesota.